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Contrave is really a combination of the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which are made up of many active ingredient, which may make them more efficient and safer. Combo-pilling will be the newest fad or in addition to this the newest ahead under scrutiny and thus it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular could be the fact that since right now there aren't any long term prescription weightloss pills that have been approved by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be authorized by the FDA. Seizures are a side effect with Contrave and shouldn't be taken in people with seizure disorders. 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